Neutrophil in sepsis: functional aberration and regulated cell death
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By
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Li Liu
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Yanli Yang
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Haixia Yang
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Meng Yang
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June 5, 2026
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Clinical Scorecard: Neutrophil Dysfunction and Regulated Cell Death in the Context of Sepsis
At a Glance
| Category | Detail |
|---|
| Condition | Sepsis |
| Key Mechanisms | Neutrophil dysfunction, aberrant activation of cell death pathways, excessive inflammatory responses. |
| Target Population | Critically ill patients, particularly those with trauma, burns, infection, or shock. |
| Care Setting | Intensive care units. |
Key Highlights
- Sepsis is a leading cause of death in critically ill patients.
- Neutrophils exhibit functional abnormalities and altered cell death patterns in sepsis.
- Inhibition of neutrophil apoptosis contributes to excessive inflammation.
- New neutrophil subsets have been identified that play critical roles in sepsis pathology.
- Targeting neutrophil cell death pathways may reduce mortality in sepsis.
Guideline-Based Recommendations
Diagnosis
- Recognize sepsis as life-threatening organ dysfunction due to dysregulated host response to infection.
Management
- Implement strategies to modulate neutrophil function and death to improve outcomes.
Monitoring & Follow-up
- Monitor neutrophil activity and inflammatory markers to assess disease progression.
Risks
- High mortality rate associated with sepsis, particularly in intensive care settings.
Patient & Prescribing Data
Patients with sepsis and septic shock.
Research indicates potential for immunomodulatory therapies targeting neutrophil dysfunction.
Clinical Best Practices
- Utilize high-throughput analytical techniques to study neutrophil subpopulations.
- Focus on the molecular mechanisms of neutrophil cell death in sepsis treatment.
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