Macronutrients tested in weight loss

Investigators compared cardiometabolic responses to matched weight loss across ketogenic, Mediterranean, and plant-forward diets.

Category	Detail
Condition	Obesity with prediabetes and hepatic steatosis
Key Mechanisms	Dietary macronutrient composition impacts insulin sensitivity and weight loss outcomes.
Target Population	Adults aged 18 to 55 years with obesity, prediabetes, and hepatic steatosis
Care Setting	Randomized clinical trial

Comparable weight loss (~10%) across three dietary approaches: ketogenic, Mediterranean, and plant-forward.
Ketogenic diet showed a greater increase in hepatic insulin sensitivity compared to other diets.
High dietary adherence (>95%) was achieved with all food provided.
Prediabetes remission rates were highest in the ketogenic group (50%).
Intrahepatic triglyceride content decreased significantly with the ketogenic diet.

Monitor insulin sensitivity and metabolic outcomes during dietary interventions.

Adults with obesity, prediabetes, and hepatic steatosis.

Very-low-carbohydrate ketogenic diet may enhance hepatic insulin sensitivity.

Provide all food to participants to enhance dietary adherence.
Regularly assess metabolic outcomes in patients undergoing dietary interventions.

Clinical Scorecard: Macronutrients tested in weight loss