Clinical Scorecard: Exploring Participant Preferences for Centralized Versus Remote Engagement in Clinical Trials: A Secondary Analysis of Nonrandomized Data
At a Glance
Category
Detail
Condition
Participant engagement in clinical trials
Key Mechanisms
Comparison of centralized versus remote trial engagement modalities
Target Population
Adolescents aged 13-17 years and young adults aged 18-21 years
Care Setting
Cincinnati Children’s Hospital Medical Center
Key Highlights
40% of participants chose centralized engagement, 49.9% remote, and 10.1% mixed.
Young adults preferred centralized visits (57.3%), while adolescent-parent dyads favored remote (68.5%).
Distance from the medical center influenced engagement modality choice.
Remote trials may enhance accessibility but could worsen engagement for some populations.
The trial achieved recruitment and visit completion targets through hybrid design.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Potential barriers for young adult engagement in fully remote studies.
Patient & Prescribing Data
Adolescents and young adults, primarily English-speaking, living within 100 miles of CCHMC.
Participants had the option of virtual or in-person visits and various biospecimen collection methods.
Clinical Best Practices
Offer flexible engagement modalities to accommodate participant preferences.
Consider demographic factors such as age and distance from research facilities in trial design.
Utilize hybrid trial designs to enhance recruitment and retention.
