Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis

Category	Detail
Condition
Key Mechanisms	Insulin resistance, metabolic dysfunction, body fat distribution, cardiovascular injury mechanisms including sympathetic activation and oxidative stress, linked to study findings.
Target Population
Care Setting

TyG-related indices are independently associated with prevalent CHD and should be considered in clinical assessments.
TyG-WWI showed the strongest association with incident MACE, indicating its potential as a key marker.
Adding TyG-WWI to conventional risk factors significantly improved CHD discrimination, suggesting its clinical utility.
Exploratory analysis suggested potential indirect pathways involving TyG indices, warranting further investigation.

Consideration of TyG-related indices for cardiovascular risk stratification, including specific interventions based on results.

TyG-WWI may serve as a candidate marker for cardiovascular risk, with recommendations for integration into treatment protocols.

Integrate metabolic dysfunction and body fat distribution assessment in OSAHS management, with specific examples of clinical workflows.

Clinical Scorecard: Relationship Between the TyG Index, Body Fat Distribution Metrics, and the Risk of CHD and MACE in Adults with OSAHS: Incremental Discrimination and Exploratory Mediation Analysis