Kounis Syndrome Induced by Relapsing Allergic Bronchopulmonary Aspergillosis: A Case Study
By
Haolei Wei
Liyan Wu
Bin Ni
Jingyu Zhang
Mengxia Xu
Liang Guo
Yanping Mao
June 9, 2026
Clinical Scorecard: Kounis Syndrome Induced by Relapsing Allergic Bronchopulmonary Aspergillosis: A Case Study
At a Glance
Category Detail
Condition Key Mechanisms Allergic acute coronary syndrome triggered by hypersensitivity reactions. Target Population Care Setting
Key Highlights
Kounis syndrome can be triggered by allergic bronchopulmonary aspergillosis (ABPA). The patient presented with acute chest tightness and dyspnea during an ABPA relapse. Laboratory tests showed eosinophilia, elevated total IgE, and myocardial injury. Coronary angiography revealed nonobstructive coronary arteries. Management included antifungal therapy, corticosteroids, and coronary vasodilators. Guideline-Based Recommendations
Diagnosis
Consider Kounis syndrome in patients with unexplained cardiopulmonary symptoms during ABPA exacerbations. Management
Utilize antifungal therapy, systemic corticosteroids, and supportive care for Kounis syndrome. Monitoring & Follow-up
Monitor cardiac biomarkers such as cardiac troponin I and B-type natriuretic peptide. Risks
Patients with severe allergic airway disease may experience cardiovascular complications. Patient & Prescribing Data
Treatment included itraconazole, piperacillin-tazobactam, and coronary vasodilators.
Clinical Best Practices
Maintain cardiovascular vigilance in patients with severe allergic airway disease. Recognize the potential for Kounis syndrome in patients with ABPA. Related Resources & Content
