Proteomics Gives Us the Cancer Traffic Report

In cancer genotyping, genomics provides the blueprint, while proteomics tells us what has been built – so let's integrate them

Category	Detail
Condition	Cancer
Key Mechanisms	Functional proteomics reveals the actual activity of proteins and signaling pathways in tumors, which can differ from genomic predictions.
Target Population	Patients with cancer undergoing precision oncology diagnostics.
Care Setting	Oncology diagnostics and treatment planning.

Genomics provides information on potential tumor behavior based on DNA alterations.
Functional proteomics assesses the actual biological activity of proteins in tumors.
Phosphorylation is a key regulatory mechanism affecting protein activity and signaling pathways.
Understanding both genomic and proteomic data is critical for effective therapy selection.
Tumors may respond differently to therapies based on their functional state, not just genomic alterations.

Incorporate functional proteomics into oncology diagnostics to better understand tumor behavior.

Consider both genomic and proteomic data when selecting targeted therapies for cancer patients.

Monitor protein activation states and signaling pathways to assess treatment response and resistance.

Relying solely on genomic data may lead to false confidence in treatment efficacy or overlook potential therapeutic options.

Patients with tumors harboring genomic alterations.

Therapeutic responses can vary significantly among patients with similar genomic profiles due to differences in functional proteomics.

Utilize multi-omic approaches combining genomics and proteomics for precision medicine.
Employ phosphoproteomics to evaluate the activation of key signaling pathways in tumors.