Intravenous-to-enteral drug substitution in the ICU: a single-centre analysis of the potential to reduce the environmental footprint of critical care - Scorecard - MDSpire
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Evaluating the Transition from Intravenous to Enteral Medications in the ICU: A Single-Center Study on Reducing the Environmental Impact of Critical Care

  • By

  • Clémence Marois

  • Maxime Gasperment

  • Adam Celier

  • Ambre Preteux

  • Grégoire Gaucher

  • Léontine Scherer

  • Nicolas Weiss

  • Kevin Bihan

  • Marie Lecronier

  • Amélie Liou

  • September 22, 2026

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Clinical Scorecard: Evaluating the Transition from Intravenous to Enteral Medications in the ICU: A Single-Center Study on Reducing the Environmental Impact of Critical Care

At a Glance

CategoryDetail
ConditionIntravenous to Enteral Medication Transition
Key MechanismsReduction of greenhouse gas emissions and prevention of administration errors through medication route reconsideration.
Target PopulationPatients in the intensive care unit (ICU) with conditions permitting enteral drug administration.
Care SettingIntensive care unit (ICU)

Key Highlights

  • 63 out of 269 intravenous medications had viable enteral counterparts.
  • 86% of eligible medications were classified as Ready for IV-to-enteral substitution.
  • Projected reductions of 12.7 tCO₂e and €73,784 in medication costs with 50% substitution.
  • Daily medication review is essential for determining treatment appropriateness.
  • Enteral absorption can be variable during critical illness.

Guideline-Based Recommendations

Diagnosis

  • Assess patient eligibility for conversion to enteral therapy based on clinical appropriateness.

Management

  • Implement a multidisciplinary approach for classifying medications for IV-to-enteral substitution.

Monitoring & Follow-up

  • Therapeutic drug monitoring may be required for medications classified as Requires monitoring before substitution.

Risks

  • Potential for administration errors and adverse drug events with IV therapy.

Patient & Prescribing Data

Patients in the ICU receiving intravenous medications.

Switching to enteral formulations can reduce environmental impact and medication costs.

Clinical Best Practices

  • Conduct daily medication reviews to assess the appropriateness of IV therapy.
  • Utilize a classification system to guide IV-to-enteral medication transitions.
  • Consider patient-specific factors such as organ dysfunction and gastrointestinal function.

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