Risk factors and postoperative complications following revision total knee arthroplasty in patients with metabolic syndrome–associated osteoarthritis: a 10-year retrospective analysis using a national inpatient database - Scorecard - MDSpire

Postoperative Outcomes and Risk Factors in Revision Total Knee Arthroplasty for Patients with Osteoarthritis Linked to Metabolic Syndrome: A Decade-Long Retrospective Study Utilizing a National Inpatient Database

  • By

  • Miaolan Yuan

  • Hao Xie

  • Yanjie He

  • Yinyin Qin

  • Jian Wang

  • July 20, 2026

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Clinical Scorecard: Postoperative Outcomes and Risk Factors in Revision Total Knee Arthroplasty for Patients with Osteoarthritis Linked to Metabolic Syndrome: A Decade-Long Retrospective Study Utilizing a National Inpatient Database

At a Glance

CategoryDetail
ConditionMetabolic Syndrome–Associated Osteoarthritis (MetS-OA)
Key MechanismsAssociation with metabolic syndrome and its components (obesity, hypertension, diabetes mellitus, hyperlipidemia)
Target PopulationPatients undergoing revision total knee arthroplasty (RTKA) aged 18 years and older
Care SettingNational Inpatient Database analysis

Key Highlights

  • Prevalence of MetS-OA among RTKA patients increased to 16.1% from 2011 to 2019.
  • Factors associated with MetS-OA include advanced age, male sex, non-White racial background, and comorbid conditions.
  • Patients with MetS-OA had longer hospital stays and higher hospitalization charges.
  • Postoperative complications were more likely in patients with MetS-OA, including acute myocardial infarction and acute renal failure.
  • In-hospital mortality rates did not significantly differ between MetS-OA and non-MetS-OA groups.

Guideline-Based Recommendations

Diagnosis

  • Identify MetS-OA based on the presence of osteoarthritis, obesity, and at least two metabolic abnormalities.

Management

  • Implement targeted preoperative optimization and standardized perioperative management strategies.

Monitoring & Follow-up

  • Monitor for postoperative complications, particularly in patients with MetS-OA.

Risks

  • Increased risk of postoperative complications and higher hospitalization charges in patients with MetS-OA.

Patient & Prescribing Data

Patients aged 18 years and older undergoing RTKA.

Higher median total hospitalization charges exceeding $1,445.50 for patients with MetS-OA.

Clinical Best Practices

  • Assess and manage comorbid conditions preoperatively.
  • Utilize a multidisciplinary approach for perioperative care.
  • Educate patients on the risks associated with MetS-OA.

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