Gut microbiota induces immune-related alterations in gene expression, RNA methylation, and metabolism in glioblastoma revealed by single-cell and spatial multi-omics - Scorecard - MDSpire
Advertisement
Gut microbiota induces immune-related alterations in gene expression, RNA methylation, and metabolism in glioblastoma revealed by single-cell and spatial multi-omics
Clinical Scorecard: Influence of Gut Microbiota on Immune-Related Gene Expression, RNA Methylation, and Metabolic Changes in Glioblastoma: Insights from Single-Cell and Spatial Multi-Omics Analysis
At a Glance
Category
Detail
Condition
Glioblastoma (GBM)
Key Mechanisms
Gut microbiota influences glioma progression through immune modulation and epigenetic regulation.
Target Population
Patients with glioblastoma
Care Setting
Oncology and neuro-oncology
Key Highlights
Antibiotic-induced gut microbiota disruption alters gene expression in glioma.
Key genes Epha6 and Tead1 are associated with glioma progression.
Reduced methionine levels linked to gut-derived metabolite changes.
Increased AC-like cells and disrupted intercellular communication observed.
EPHA pathway proposed as a biomarker for immune-mediated tumor modulation.
Guideline-Based Recommendations
Diagnosis
Utilize multi-omics approaches for comprehensive glioma characterization.
Management
Consider the role of gut microbiota in glioma treatment strategies.
Monitoring & Follow-up
Monitor changes in immune signaling and metabolite levels in glioma patients.
Risks
Potential for dysbiosis to exacerbate glioma progression.
Patient & Prescribing Data
Patients with glioblastoma undergoing treatment.
Antibiotic treatment may influence tumor biology and response to therapies.
Clinical Best Practices
Integrate gut microbiota assessment in glioma patient management.
Explore the therapeutic potential of targeting the gut-brain axis.
