Persistent neuropsychiatric dysfunction following chronic tiletamine-containing e-cigarette use: a case report
By
Liu Liu
Qi Zhou
Jinhong Chen
June 19, 2026
Clinical Scorecard: Long-term neuropsychiatric impairment linked to chronic use of tiletamine-infused e-cigarettes: a case study
At a Glance
Category Detail
Condition Chronic use of tiletamine-infused e-cigarettes Key Mechanisms Dissociative anesthetic effects leading to neuropsychiatric dysfunction Target Population Young adults with chronic e-cigarette use Care Setting Addiction Medicine Center
Key Highlights
Progressive neuropsychiatric symptoms observed after chronic tiletamine use Symptoms included gait instability, dysarthria, and emotional instability Electroencephalography suggested functional brain involvement Symptoms improved after discontinuation of tiletamine use Patient experienced marked craving for tiletamine-containing e-cigarettes Guideline-Based Recommendations
Diagnosis
Utilize rating scales such as PHQ-9 and GAD-7 for assessing depressive and anxiety symptoms Conduct neurological examinations to assess ataxic manifestations Management
Comprehensive treatment following cessation of tiletamine use Consider traditional Chinese medicine and acupuncture as adjunct therapies Monitoring & Follow-up
Regular assessment of depressive symptoms, anxiety symptoms, ataxia, and craving severity Risks
Potential for persistent neuropsychiatric dysfunction and dependence-related features Patient & Prescribing Data
22-year-old male with chronic e-cigarette use
Improvement of symptoms observed after cessation of tiletamine-containing e-cigarettes
Clinical Best Practices
Monitor for signs of dependence and neuropsychiatric symptoms in e-cigarette users Educate patients on the risks associated with illicit substances in e-cigarettes Related Resources & Content
