HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer - Scorecard - MDSpire

HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer

  • By

  • Vahid Akbari

  • Alexandra Morgan

  • Michie Yasuda

  • Ulrich Schlecht

  • Sylvie McNamara

  • Hosseinali Asgharian

  • Christopher Tam

  • Rena Adachi

  • Elisa Contreras

  • Zhipei Gracie Du

  • Sandra Siemann

  • Hahn Zhao

  • Jeyashree Ashok Balasubramanian

  • Diane Balallo

  • Devanshee Sanghvi

  • Tarini Shankar

  • Sanjucta Dutta

  • Stefan Riedel

  • Stefanie Mattson

  • Daniel Burukhin

  • Florian Rubelt

  • Sowmi Utiramerur

  • Dinesh Kumar

  • Hamid Mirebrahim

  • Ramy Arnaout

  • June 18, 2026

  • 0 min

Share

Clinical Scorecard: HuBIE: An Encyclopedia of Human Blood Immunome Featuring TCRs and BCRs in Cancer and Bloodstream Infections

At a Glance

CategoryDetail
ConditionCancer and Bloodstream Infections
Key MechanismsT and B cell receptor diversity through somatic recombination and junctional diversity.
Target PopulationPatients with bloodstream infections, cancer, or both.
Care SettingReal-world clinical settings.

Key Highlights

  • Comprises immune-repertoire data from 2,614 samples from 1,941 participants.
  • Identifies significant differences in TCR and BCR composition across ethnic groups.
  • Demonstrates that greater immunological diversity is associated with improved survival for elderly participants.
  • Profiles TCR and BCR diversity to inform diagnostics and therapeutic strategies.
  • Utilizes Roche’s immunoPETE platform for simultaneous sequencing of TCR and BCR.

Guideline-Based Recommendations

Diagnosis

  • Utilize immune-repertoire sequencing for detailed profiling of TCR and BCR diversity.

Management

  • Implement findings to develop personalized immunotherapies and assess treatment outcomes.

Monitoring & Follow-up

  • Track immune responses to cancer and bacterial infections through immune-repertoire data.

Risks

  • Consider limitations due to small cohort sizes and heterogeneous sample processing.

Patient & Prescribing Data

Real-world patients seeking care for bloodstream infections and cancer.

Longitudinal samples provide insights into treatment patterns and outcomes.

Clinical Best Practices

  • Leverage large-scale immune-repertoire data for personalized medicine.
  • Ensure diverse patient representation in immune-repertoire studies.
  • Utilize comprehensive clinical annotation to support immunotherapy research.

Related Resources & Content

Original Source(s)

HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer

  • by Vahid Akbari, Alexandra Morgan, Michie Yasuda, Ulrich Schlecht, Sylvie McNamara, Hosseinali Asgharian, Christopher Tam, Rena Adachi, Elisa Contreras, Zhipei Gracie Du, Sandra Siemann, Hahn Zhao, Jeyashree Ashok Balasubramanian, Diane Balallo, Devanshee Sanghvi, Tarini Shankar, Sanjucta Dutta, Stefan Riedel, Stefanie Mattson, Daniel Burukhin, Florian Rubelt, Sowmi Utiramerur, Dinesh Kumar, Hamid Mirebrahim, Ramy Arnaout

  • June 18, 2026

Related Content

The quiet joy of being an oncologist

Ipilimumab and nivolumab for cancer treatment: a pharmacovigilance study based on the FDA adverse event reporting system database

Clinical outcomes of tebentafusp in metastatic uveal melanoma: a systematic review and single-arm meta-analysis