Impact of Gestational Weight Gain on Pregnancy-Related Breast Cancer and Validation of a Nomogram
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By
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Chenguang Liu
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Ruifeng Wang
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Shoujun Wang
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Shiyang Liu
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Xinhong Wu
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Weihong Zheng
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Shuyu Li
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Tianyao Yu
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Jie Hao
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Lin Zhang
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November 29, 2025
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Clinical Scorecard: Impact of Gestational Weight Gain on Pregnancy-Related Breast Cancer and Validation of a Nomogram
At a Glance
| Category | Detail |
|---|
| Condition | Pregnancy-Associated Breast Cancer (PABC) |
| Key Mechanisms | Hormonal fluctuation, immune changes, and breast involution contribute to PABC progression. |
| Target Population | Women diagnosed with breast cancer during pregnancy or within 1 year postpartum. |
| Care Setting | Multi-center cohort study across hospitals. |
Key Highlights
- Incidence of PABC is rising, with 13 cases per 100,000 deliveries.
- PABC has worse prognosis compared to non-PABC, especially in late pregnancy or early postpartum.
- Gestational weight gain (GWG) categorized into normal, inadequate, and excessive based on pre-pregnancy BMI.
Guideline-Based Recommendations
Diagnosis
- Breast cancer staging according to the 8th edition of AJCC.
- Molecular subtypes classified based on the 2013 St. Gallen Consensus.
Management
- Neoadjuvant chemotherapy regimens based on anthracyclines or taxanes.
Monitoring & Follow-up
- Follow-up for disease-free survival (DFS) until 5-10 years postpartum.
Risks
- Increased risk of PABC linked to gestational diabetes, preeclampsia, and being overweight.
Patient & Prescribing Data
Women with PABC from a multi-center cohort study.
Treatment strategies included surgery, chemotherapy, and targeted therapies.
Clinical Best Practices
- Identify and monitor risk factors for PABC.
- Utilize nomograms for estimating DFS in PABC patients.
References
