Influence of Cardiovascular and Metabolic Comorbidities on the Severity and Outcomes of Hospital-Acquired Sepsis in ICU Patients: A Case-Control Analysis - Scorecard - MDSpire

Influence of Cardiovascular and Metabolic Comorbidities on the Severity and Outcomes of Hospital-Acquired Sepsis in ICU Patients: A Case-Control Analysis

  • By

  • Amrita Roy

  • Vignesh Krishnasamy

  • Sourabh Mitra

  • Sudip Banerjee

  • Tapan Kumar Dutta

  • Nachimuthu Senthil Kumar

  • Swagnik Roy

  • February 2, 2026

  • 0 min

Share

Clinical Scorecard: Influence of Cardiovascular and Metabolic Comorbidities on the Severity and Outcomes of Hospital-Acquired Sepsis in ICU Patients: A Case-Control Analysis

At a Glance

CategoryDetail
ConditionHospital-Acquired Sepsis
Key MechanismsInvolves dysregulated host response to infection, activation of inflammatory pathways, and cytokine release.
Target PopulationICU patients with cardiovascular and metabolic comorbidities.
Care SettingTertiary care hospital ICU.

Key Highlights

  • Sepsis accounts for 19.7% of global mortality.
  • Cytokines play a crucial role in the pathogenesis of sepsis.
  • Septic shock has a mortality rate of 40-50%.
  • Cardiovascular comorbidities exacerbate sepsis severity.
  • Inflammatory markers can indicate prognosis in sepsis patients.

Guideline-Based Recommendations

Diagnosis

  • Sepsis diagnosed per Sepsis-3 criteria with evidence of organ dysfunction.

Management

  • Early identification and treatment of infections with appropriate antimicrobial therapy.

Monitoring & Follow-up

  • Use of SOFA score to assess disease severity upon ICU admission.

Risks

  • Increased mortality and long-term cardiovascular complications in patients with pre-existing cardiac conditions.

Patient & Prescribing Data

Patients with sepsis requiring ICU admission, particularly those with cardiovascular and metabolic comorbidities.

Procalcitonin (PCT) and inflammatory cytokines (IL-6, TNF-α, IL-10) are important for assessing infection and inflammation.

Clinical Best Practices

  • Monitor inflammatory markers to guide prognosis.
  • Implement early sepsis protocols in ICU settings.
  • Consider comorbidities when assessing sepsis severity and treatment plans.

References

Original Source(s)

Influence of Cardiovascular and Metabolic Comorbidities on the Severity and Outcomes of Hospital-Acquired Sepsis in ICU Patients: A Case-Control Analysis

  • by Amrita Roy, Vignesh Krishnasamy, Sourabh Mitra, Sudip Banerjee, Tapan Kumar Dutta, Nachimuthu Senthil Kumar, Swagnik Roy

  • February 2, 2026

Related Content

Optimizing healthcare resources in pyogenic liver abscess: a dual-threshold HDL-CRP model for predicting hospitalization duration across multi-cohorts

Clinical case study: Bilateral scrotal and right leg necrotizing fasciitis due to Streptococcus pyogenes in a healthy male patient: a comprehensive diagnostic and treatment evaluation

Off by a beat: the effects of temporal misalignment in reinforcement learning for sepsis treatment