Keratoconus in Hormonal Flux
Is it time to rethink the importance of hormonal changes on keratoconus pathology?
Clinical Scorecard: Keratoconus in Hormonal Flux
At a Glance
Category Detail
Condition Keratoconus (KCN) Key Mechanisms Hormonal fluctuations, particularly involving the hypothalamic–pituitary–gonadal (HPG) axis hormones. Target Population Adults from early twenties to late fifties, particularly during significant hormonal changes. Care Setting Ophthalmology clinics and practices.
Key Highlights
Hormonal fluctuations, especially during pregnancy, are linked to KCN onset and progression. Elevated DHEAS levels consistently reported in KCN patients. Systematic review included 26 studies with over 4,200 participants. Integration of hormonal history into KCN risk assessment is recommended. Proposed targeted screening pathways for vulnerable groups. Guideline-Based Recommendations
Diagnosis
Consider hormonal history in KCN risk assessment. Management
Monitor hormonal levels during significant hormonal changes. Monitoring & Follow-up
Be alert to periods of hormonal fluctuation as potential windows of vulnerability. Risks
Increased risk of KCN onset or progression linked to hormonal shifts. Patient & Prescribing Data
Adults experiencing hormonal changes, including pregnancy and those on hormone therapy.
Hormonal therapies may influence KCN progression; careful monitoring is advised.
Clinical Best Practices
Implement proactive screening for KCN in patients with known hormonal fluctuations. Educate patients on the potential impact of hormonal changes on KCN. Related Resources & Content
