Management of an Elderly Patient with Toxic Epidermal Necrolysis: A Case Study
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By
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Danqiong Wang
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Mengjiao Yuan
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Ying Ying
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April 23, 2026
Clinical Scorecard: Management of an Elderly Patient with Toxic Epidermal Necrolysis: A Case Study
At a Glance
| Category | Detail |
|---|
| Condition | Toxic Epidermal Necrolysis (TEN) |
| Key Mechanisms | Induced by medications leading to extensive apoptosis and necrosis of epidermal keratinocytes. |
| Target Population | Elderly patients with compromised immunity and multiple comorbidities. |
| Care Setting | Intensive Care Unit (ICU) |
Key Highlights
- Patient presented with 55% body surface area skin involvement.
- Mortality rate for TEN is 30-50%.
- Comprehensive nursing strategy improved outcomes and reduced complication risks.
- Wound healing achieved nearly complete epithelialization in 17 days.
- No severe ocular complications developed.
Guideline-Based Recommendations
Diagnosis
- Diagnosis based on clinical presentation and extent of skin detachment.
Management
- Individualized nursing plan with multidisciplinary collaboration.
- Staged wound care and infection prevention.
Monitoring & Follow-up
- Regular assessment of infection markers and wound healing progress.
Risks
- High risk of multiple organ failure and complications in elderly patients.
Patient & Prescribing Data
Elderly patients with TEN and multiple comorbidities.
Use of yellow light irradiation and epidermal growth factor to promote wound healing.
Clinical Best Practices
- Implement full-process protective isolation and strict aseptic techniques.
- Utilize targeted nursing measures for vulnerable mucous membranes.
- Adopt innovative adhesive-free dressing fixation strategies for intravenous access.
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