Management of an Elderly Patient with Toxic Epidermal Necrolysis: A Case Study
By
Danqiong Wang
Mengjiao Yuan
Ying Ying
April 23, 2026
Clinical Scorecard: Management of an Elderly Patient with Toxic Epidermal Necrolysis: A Case Study
At a Glance
Category Detail
Condition Toxic Epidermal Necrolysis (TEN) Key Mechanisms Induced by medications leading to extensive apoptosis and necrosis of epidermal keratinocytes. Target Population Elderly patients with compromised immunity and multiple comorbidities. Care Setting Intensive Care Unit (ICU)
Key Highlights
Patient presented with 55% body surface area skin involvement. Mortality rate for TEN is 30-50%. Comprehensive nursing strategy improved outcomes and reduced complication risks. Wound healing achieved nearly complete epithelialization in 17 days. No severe ocular complications developed. Guideline-Based Recommendations
Diagnosis
Diagnosis based on clinical presentation and extent of skin detachment. Management
Individualized nursing plan with multidisciplinary collaboration. Staged wound care and infection prevention. Monitoring & Follow-up
Regular assessment of infection markers and wound healing progress. Risks
High risk of multiple organ failure and complications in elderly patients. Patient & Prescribing Data
Elderly patients with TEN and multiple comorbidities.
Use of yellow light irradiation and epidermal growth factor to promote wound healing.
Clinical Best Practices
Implement full-process protective isolation and strict aseptic techniques. Utilize targeted nursing measures for vulnerable mucous membranes. Adopt innovative adhesive-free dressing fixation strategies for intravenous access. References
