Clinical Scorecard: Comparing Race and Ethnicity Recorded in a Children’s Oncology Group Trial With Parent-Reported Information
At a Glance
Category
Detail
Condition
Clinical topic addressed by the source article: Comparing Race and Ethnicity Recorded in a Children’s Oncology Group Trial With Parent-Reported Information
Key Mechanisms
Mechanisms or clinical associations described in the source article.
Target Population
Population described in the source article.
Care Setting
A randomized phase III COG National Clinical Trials Network trial conducted at 217 sites in the United States and Canada; this analysis included US participants.
Key Highlights
Trial-collected race and ethnicity were missing for 8.7% of US participants, compared with 1.0% for parent-reported information.
Agreement with parent report was moderate for race (72.8%; κ = 0.45), substantial for ethnicity (83.0%; κ = 0.65), and substantial for the combined measure (78.6%; κ = 0.67).
The trial’s combined race and ethnicity classification differed from parent report for about 1 in 5 children.
Concordance was lowest for parent-reported multiracial participants: 11.6%; 47.8% were classified by the trial as non-Hispanic White.
Guideline-Based Recommendations
Diagnosis
The analysis used parent-reported race and ethnicity as the reference standard for assessing concordance with trial-collected data.
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
US participants aged 1 to 9 years with newly diagnosed B-cell ALL enrolled in COG AALL1731; parents or guardians could complete the survey in English, Spanish, or French.
This study evaluated race and ethnicity data collection, not treatment efficacy or prescribing. Parent-reported information was missing less often than trial-collected information.
by Callie Fry, Eva Robinson, Edie Weller, Morgan A. Paul, Rahela Aziz-Bose, Leanne Duhaney, McKenzie Griffin, Kristine Karvonen, Colleen A. Kelly, Sunyu Kang, Haley Newman, Puja J. Umaretiya, Daniel J. Zheng, Sumit Gupta, Rachel E. Rau, David T. Teachey, Sarah Alexander, John A. Kairalla, Kira Bona
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