Seminal fibrils may facilitate mpox infection
Seminal fluid increased mpox virus infection across primary cells and viral isolates, with semen-derived amyloid fibrils promoting viral attachment and uptake.
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By
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Andrea Surnit
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September 9, 2026
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Clinical Scorecard: Seminal fibrils may facilitate mpox infection
At a Glance
| Category | Detail |
|---|
| Condition | mpox infection |
| Key Mechanisms | Seminal fluid enhances mpox virus infection through increased viral attachment and uptake, facilitated by semen-derived amyloid fibrils. |
| Target Population | Healthy individuals and those potentially exposed to mpox virus. |
| Care Setting | Laboratory and ex vivo experimental models. |
Key Highlights
- Seminal fluid increased mpox infection 2.2- to 4.1-fold in primary fibroblasts and keratinocytes.
- Semen-derived fibrils SEVI and SEM enhanced mpox infection in a dose-dependent manner.
- Infection rates increased significantly in corneal epithelial cells and other immune cell models with SEVI.
- Tecovirimat and brincidofovir retained antiviral activity under SEVI-enhanced conditions.
Guideline-Based Recommendations
Diagnosis
- Further studies needed to establish the impact of seminal fluid on mpox transmission.
Management
- Consider the role of seminal fluid in mpox infection dynamics.
Monitoring & Follow-up
- Monitor infection rates in populations with potential exposure to seminal fluid.
Risks
- Increased infectivity observed with seminal fluid may influence transmission dynamics.
Patient & Prescribing Data
Individuals at risk of mpox infection, particularly during sexual activity.
Antiviral treatments remain effective under SEVI-enhanced conditions, though efficacy may vary.
Clinical Best Practices
- Conduct in vivo studies to further understand the role of seminal fluid in mpox transmission.
- Evaluate the impact of other bodily fluids on mpox infection during sexual activity.
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