Seminal fibrils may facilitate mpox infection
Seminal fluid increased mpox virus infection across primary cells and viral isolates, with semen-derived amyloid fibrils promoting viral attachment and uptake.
By
Andrea Surnit
September 9, 2026
Clinical Scorecard: Seminal fibrils may facilitate mpox infection
At a Glance
Category Detail
Condition mpox infection Key Mechanisms Seminal fluid enhances mpox virus infection through increased viral attachment and uptake, facilitated by semen-derived amyloid fibrils. Target Population Healthy individuals and those potentially exposed to mpox virus. Care Setting Laboratory and ex vivo experimental models.
Key Highlights
Seminal fluid increased mpox infection 2.2- to 4.1-fold in primary fibroblasts and keratinocytes. Semen-derived fibrils SEVI and SEM enhanced mpox infection in a dose-dependent manner. Infection rates increased significantly in corneal epithelial cells and other immune cell models with SEVI. Tecovirimat and brincidofovir retained antiviral activity under SEVI-enhanced conditions. Guideline-Based Recommendations
Diagnosis
Further studies needed to establish the impact of seminal fluid on mpox transmission. Management
Consider the role of seminal fluid in mpox infection dynamics. Monitoring & Follow-up
Monitor infection rates in populations with potential exposure to seminal fluid. Risks
Increased infectivity observed with seminal fluid may influence transmission dynamics. Patient & Prescribing Data
Individuals at risk of mpox infection, particularly during sexual activity.
Antiviral treatments remain effective under SEVI-enhanced conditions, though efficacy may vary.
Clinical Best Practices
Conduct in vivo studies to further understand the role of seminal fluid in mpox transmission. Evaluate the impact of other bodily fluids on mpox infection during sexual activity. Related Resources & Content
