Pre-transplant microRNA serum profiles and association with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation - Scorecard - MDSpire

Pre-transplant microRNA serum profiles and association with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation

  • By

  • Guido Smits

  • Silje Johansen

  • Kristin Paulsen Rye

  • Kimberley Joanne Hatfield

  • Franziska Görtler

  • Guro Kristin Melve

  • Håkon Reikvam

  • May 28, 2026

  • 0 min

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Clinical Scorecard: Serum microRNA Profiles Prior to Transplantation and Their Relationship with Acute Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation

At a Glance

CategoryDetail
ConditionAcute graft-versus-host disease (aGVHD)
Key MechanismsCirculating microRNAs (miRNAs) as potential non-invasive biomarkers for early detection
Target PopulationAllogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients
Care SettingTransplantation centers

Key Highlights

  • 23% of allo-HSCT recipients developed aGVHD grade II–IV
  • Eight pretransplant miRNAs identified as predictive for aGVHD development
  • Predictive model achieved an AUC of 0.855
  • Cluster analysis revealed distinct aGVHD risk profiles among patients
  • EASIX score correlated with additional miRNAs reflecting endothelial stress

Guideline-Based Recommendations

Diagnosis

  • Utilize serum miRNA profiles for early prediction of aGVHD

Management

  • Consider personalized GVHD prophylaxis based on miRNA profiling

Monitoring & Follow-up

  • Integrate miRNA profiling into pre-transplant assessment

Risks

  • Early mortality and relapse rates post-transplantation

Patient & Prescribing Data

78 allo-HSCT recipients, average age 56 years

94% received cyclosporine A and methotrexate as GVHD prophylaxis

Clinical Best Practices

  • Implement early risk stratification using pre-transplant miRNA signatures
  • Monitor EASIX score alongside miRNA profiles for comprehensive risk assessment

Related Resources & Content

    Original Source(s)

    Pre-transplant microRNA serum profiles and association with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation

    • by Guido Smits, Silje Johansen, Kristin Paulsen Rye, Kimberley Joanne Hatfield, Franziska Görtler, Guro Kristin Melve, Håkon Reikvam

    • May 28, 2026

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