Unraveling the role of PPFIA1 in cancer: a comprehensive multi-omics analysis and functional validation from pan-cancer to pancreatic cancer - Scorecard - MDSpire
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Unraveling the role of PPFIA1 in cancer: a comprehensive multi-omics analysis and functional validation from pan-cancer to pancreatic cancer
Clinical Scorecard: Investigating the Function of PPFIA1 in Oncology: An In-Depth Multi-Omics Study and Validation from Pan-Cancer to Pancreatic Cancer
At a Glance
Category
Detail
Condition
Pancreatic Cancer
Key Mechanisms
Modulates cell adhesion, signal transduction, and cytoskeletal dynamics.
Target Population
Patients with pancreatic cancer and other malignancies.
Care Setting
Oncology research and clinical trials.
Key Highlights
PPFIA1 is overexpressed in pancreatic adenocarcinoma compared to non-tumor tissue.
High PPFIA1 expression correlates with adverse prognosis in pancreatic cancer.
Knockdown of PPFIA1 suppresses cell proliferation, migration, and invasion in pancreatic cancer models.
PPFIA1 is associated with superior responses to immunotherapy in pan-cancer cohorts.
Genomic alterations of PPFIA1 include amplifications and mutations across various cancers.
Guideline-Based Recommendations
Diagnosis
Evaluate PPFIA1 expression levels for prognostic assessment in pancreatic cancer.
Management
Consider PPFIA1 as a potential therapeutic target in precision oncology.
Monitoring & Follow-up
Monitor PPFIA1 levels to assess treatment response and prognosis.
Risks
High PPFIA1 expression may indicate a higher risk of poor outcomes in pancreatic cancer.
Patient & Prescribing Data
Patients diagnosed with pancreatic cancer and other malignancies.
PPFIA1 may serve as a biomarker for immunotherapy efficacy.
Clinical Best Practices
Integrate multi-omics data for comprehensive evaluation of PPFIA1 in cancer.
Utilize external cohorts for validation of PPFIA1 expression and prognostic significance.
