Retrospective evaluation of the treatment of term newborns with hypernatraemic dehydration over the last decade
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By
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Ünal Ünal
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Can Akyıldız
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Funda Erdoğan
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Nuray Duman
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Hasan Özkan
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July 10, 2026
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Clinical Scorecard: A Decade-Long Retrospective Analysis of Fluid Therapy for Term Newborns with Hypernatraemic Dehydration
At a Glance
| Category | Detail |
|---|
| Condition | Hypernatraemic Dehydration in Newborns |
| Key Mechanisms | Fluid therapy with varying sodium concentrations to manage serum sodium levels. |
| Target Population | Term newborns with hypernatraemic dehydration (serum sodium > 146 mmol/L). |
| Care Setting | Neonatal Intensive Care Units (NICUs) |
Key Highlights
- Hypotonic fluids resulted in a more rapid decline in serum sodium compared to isotonic fluids.
- No significant difference in mortality or morbidity between fluid types.
- Higher proportion of infants receiving hypotonic fluids exceeded the recommended correction rate of 0.5 mmol/L/hour.
Guideline-Based Recommendations
Diagnosis
- Hypernatraemia is defined as a serum sodium level of 146 mmol/L or higher.
Management
- Isotonic fluids (0.9% NaCl) are recommended for term newborns after the eighth postnatal day.
Monitoring & Follow-up
- Hourly sodium changes should be monitored during fluid therapy.
Risks
- Potential for severe neurological damage and thrombotic complications associated with hypernatraemia.
Patient & Prescribing Data
Newborns admitted to NICU with hypernatraemic dehydration.
Isotonic fluids are associated with a slower decline in serum sodium levels.
Clinical Best Practices
- Standardize guidelines for fluid therapy in hypernatraemic dehydration based on evidence.
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