High progesterone may be tied to syringoma - Scorecard - MDSpire
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High progesterone may be tied to syringoma

Elevated levels occurred in 29% of women with the condition compared with 6% of controls in a cross-sectional study.

  • By

  • Andrea Surnit

  • August 31, 2026

  • 3 min

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Clinical Scorecard: High progesterone may be tied to syringoma

At a Glance

CategoryDetail
ConditionSyringoma
Key MechanismsPossible hormonal association with elevated serum progesterone affecting sweat gland activity and structure.
Target PopulationWomen aged 18 years or older with regular menstrual cycles.
Care SettingSingle-center observational study

Key Highlights

  • 29% of patients with syringoma had high serum progesterone compared to 6% of controls.
  • Patients with syringoma had 6.6 times the odds of high serum progesterone.
  • Localized syringoma was the most common form, affecting the periorbital region.

Guideline-Based Recommendations

Diagnosis

  • Syringoma diagnosed using clinical and dermoscopic examination.

Management

  • Further prospective research needed to explore the role of progesterone.

Monitoring & Follow-up

  • Blood samples collected during the luteal phase for progesterone measurement.

Risks

  • Study limitations include small sample size and lack of adjustment for confounders.

Patient & Prescribing Data

Women with syringoma aged 18 years or older.

No specific treatment insights provided; further research needed.

Clinical Best Practices

  • Consider hormonal factors in patients with syringoma.
  • Standardized sampling timing and histopathologic confirmation recommended for future studies.

Related Resources & Content

Original Source(s)

High progesterone may be tied to syringoma

  • by Andrea Surnit

  • August 31, 2026

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