Acute Kidney Injury After Pediatric Heart Transplant: The Impact of Intraoperative Hemodynamics Using High-Fidelity Data - Scorecard - MDSpire
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Intraoperative Hemodynamics and Their Influence on Acute Kidney Injury Following Heart Transplantation in Children: Insights from High-Fidelity Data

  • By

  • Matthew Cummins

  • Brian Madden

  • Philip T. Thrush

  • Rajit Basu

  • Rohit S. Loomba

  • July 16, 2026

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Clinical Scorecard: Intraoperative Hemodynamics and Their Influence on Acute Kidney Injury Following Heart Transplantation in Children: Insights from High-Fidelity Data

At a Glance

CategoryDetail
ConditionAcute Kidney Injury following Heart Transplantation in Children
Key MechanismsIntraoperative mean arterial pressure, central venous pressure, and renal near infrared spectroscopy
Target PopulationPediatric patients undergoing heart transplantation
Care SettingSingle-center, retrospective study at a pediatric hospital

Key Highlights

  • Incidence of acute kidney injury post-heart transplant in children ranges from 49% to 66%.
  • Nearly 10% of patients may require dialysis post-transplant.
  • Intraoperative monitoring may help predict postoperative renal dysfunction.

Guideline-Based Recommendations

Diagnosis

  • Use creatinine criteria set forth by the Kidney Disease: Improving Global Outcomes initiative for staging acute kidney injury.

Management

  • Monitor intraoperative hemodynamics to assess risk for acute kidney injury.

Monitoring & Follow-up

  • Collect serum creatinine values pre- and post-transplant for acute kidney injury assessment.

Risks

  • Risk factors for acute kidney injury include underlying cardiac diagnosis, vasoactive requirement, and cardiopulmonary bypass time.

Patient & Prescribing Data

Patients under 18 years old undergoing orthotopic heart transplant.

Intraoperative physiologic data may inform management strategies to reduce acute kidney injury risk.

Clinical Best Practices

  • Utilize renal near infrared spectroscopy for real-time assessment of renal perfusion.
  • Implement strategies to optimize intraoperative mean arterial pressure and central venous pressure.

Related Resources & Content

Original Source(s)

Acute Kidney Injury After Pediatric Heart Transplant: The Impact of Intraoperative Hemodynamics Using High-Fidelity Data

  • by Matthew Cummins, Brian Madden, Philip T. Thrush, Rajit Basu, Rohit S. Loomba

  • July 16, 2026

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