The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis - Scorecard - MDSpire
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The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis
Clinical Scorecard: The Impact of Diabetes on the Relationship Between Triglyceride to HDL Cholesterol Ratio and Cardiovascular Risk: A Systematic Review and Meta-Analysis
At a Glance
Category
Detail
Condition
Cardiovascular Disease (CVD)
Key Mechanisms
Association between triglyceride to HDL cholesterol (TG/HDL-C) ratio and cardiovascular events, modified by diabetes status.
Target Population
Adults aged > 18 years, including individuals with and without diabetes.
Care Setting
Clinical assessment of cardiovascular risk using lipid-related indices.
Key Highlights
The TG/HDL-C ratio is associated with cardiovascular events and all-cause mortality regardless of diabetes status.
Stronger associations with stroke and coronary heart disease were observed in individuals with diabetes.
The study included 27 cohort studies with a total of 949,043 participants.
Guideline-Based Recommendations
Diagnosis
Evaluate TG/HDL-C ratio as a potential indicator of cardiovascular risk.
Management
Consider diabetes status when assessing cardiovascular risk associated with TG/HDL-C ratio.
Monitoring & Follow-up
Monitor TG/HDL-C levels in both diabetic and non-diabetic populations for cardiovascular risk assessment.
Risks
Increased risk of stroke and coronary heart disease in diabetic individuals with elevated TG/HDL-C ratio.
Patient & Prescribing Data
Adults with and without diabetes.
Higher TG/HDL-C levels are linked to atherosclerotic progression and cardiovascular events.
Clinical Best Practices
Utilize TG/HDL-C ratio as a simple, cost-effective indicator of insulin resistance and lipid metabolism disorders.
Incorporate diabetes status into cardiovascular risk assessments.
