Intervention–analog association between traditional Chinese medicine syndrome load and lipid/C-reactive protein biomarkers: a single-center retrospective cohort study using target trial emulation - Scorecard - MDSpire
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Intervention–analog association between traditional Chinese medicine syndrome load and lipid/C-reactive protein biomarkers: a single-center retrospective cohort study using target trial emulation
Clinical Scorecard: Association of Traditional Chinese Medicine Syndrome Load with Lipid and C-Reactive Protein Biomarkers: A Retrospective Cohort Study Utilizing Target Trial Emulation at a Single Center
At a Glance
Category
Detail
Condition
Traditional Chinese Medicine Syndrome
Key Mechanisms
Association with lipid and inflammatory biomarkers.
Target Population
Adults with structured TCM assessments.
Care Setting
Single-center retrospective cohort study.
Key Highlights
Higher syndrome load associated with increased triglycerides, LDL-C, and CRP levels.
Study included 1,472 adults with repeated biochemical measurements over 90 days.
CFA/IRT models demonstrated good fit and supported metric/scalar invariance.
Guideline-Based Recommendations
Diagnosis
Utilize syndrome differentiation for individualized diagnosis in TCM.
Management
Consider syndrome load in cardiometabolic risk stratification.
Monitoring & Follow-up
Monitor lipid and CRP levels in patients with higher syndrome load.
Risks
Increased risk of dyslipidemia and elevated CRP associated with higher syndrome load.
Patient & Prescribing Data
Adults, particularly those aged ≥65 years, with diabetes or BMI ≥ 28.
Syndrome load may inform personalized management strategies.
Clinical Best Practices
Employ target trial emulation for observational analyses.
Use double machine learning and inverse probability of treatment weighting for robust estimations.
Validate syndrome load index for integration into conventional risk assessments.
