Targeting Mitochondrial Dynamics with Herbal Extracts in Atherosclerosis Induced by Low-Density Lipoprotein: An In Vitro Study
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By
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Zhanna Dzampaeva
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Rodion Saveljev
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July 21, 2026
Clinical Scorecard: Targeting Mitochondrial Dynamics with Herbal Extracts in Atherosclerosis Induced by Low-Density Lipoprotein: An In Vitro Study
At a Glance
| Category | Detail |
|---|
| Condition | Atherosclerosis |
| Key Mechanisms | Mitochondrial dysfunction, fission/fusion dynamics, mitophagy, antioxidant defense |
| Target Population | Individuals at risk for atherosclerosis due to LDL accumulation |
| Care Setting | In vitro study |
Key Highlights
- Ethanolic extracts from Rosmarinus officinalis, Cynara cardunculus, and Myrtus communis protect endothelial cells from ox-LDL-induced injury.
- Extracts modulate mitochondrial dynamics by downregulating pro-fission proteins and upregulating fusion proteins.
- Cynara cardunculus enhances ubiquitin-dependent mitophagy, while Rosmarinus officinalis and Myrtus communis promote receptor-mediated clearance.
- All extracts upregulated antioxidant enzymes and suppressed pro-inflammatory markers.
Guideline-Based Recommendations
Diagnosis
- Assess mitochondrial dysfunction in patients with early atherosclerosis.
Management
- Consider herbal extracts as adjunctive therapies targeting mitochondrial quality control.
Monitoring & Follow-up
- Evaluate mitochondrial dynamics and oxidative stress markers in patients.
Risks
- Monitor for potential interactions with other therapies targeting lipid levels.
Patient & Prescribing Data
Patients with early signs of atherosclerosis or elevated LDL levels.
Polyphenol-rich herbal extracts may offer a novel approach to mitigate endothelial damage.
Clinical Best Practices
- Incorporate assessment of mitochondrial function in cardiovascular risk evaluations.
- Explore the use of standardized herbal formulations in clinical settings.
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