Defining failure is not enough By Mark H. Nelson June 6, 2026 0 min Eye Share Summary Listen Insight Report Clinical Scorecard Quiz Top Institutions Topic Commentary Clinical Scorecard: Understanding the Limitations of Defining Treatment Failure At a Glance CategoryDetail Condition Key MechanismsPersistent or recurrent exudation reflects underlying biological pathways sustaining leakage, including VEGF dependence and other drivers. Target Population Care Setting Key Highlights Guideline-Based Recommendations Diagnosis Management Adjust treatment based on observed patterns of response rather than uniform definitions of failure. Monitoring & Follow-up Risks Patient & Prescribing Data Patients with varying responses to anti-VEGF therapy. Durability and response patterns can guide treatment decisions and indicate underlying biology. Clinical Best Practices Related Resources & Content Study on Mechanism-Matched EndotypesTENAYA and LUCERNE trialsEVEREST II studyImplications of VEGF dependenceBiomarker integration in trials
