Cerebral perfusion pressure trajectories and cumulative exposure metrics predict in-hospital mortality in acute brain injury
By
Juan Wang
Hai-Bo Li
Man-Man Xu
Wen-Juan Li
Chun-Hua Hang
Peng-Lai Zhao
May 22, 2026
Clinical Scorecard: Predictive Value of Cerebral Perfusion Pressure Patterns and Cumulative Metrics for In-Hospital Mortality in Acute Brain Injury Patients
At a Glance
Category Detail
Condition Acute Brain Injury (ABI) Key Mechanisms Cerebral perfusion pressure (CPP) dynamics and cumulative metrics Target Population Adults with ABI including traumatic brain injury, acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage Care Setting Intensive Care Unit (ICU)
Key Highlights
Four CPP trajectory phenotypes identified: Stable Normal, Gradual Recovery, Labile Improvement, Rapid Decline Mortality risk increases progressively from Stable Normal to Rapid Decline phenotype Higher cumulative CPP metrics are associated with lower in-hospital mortality CPP trajectory provides modest incremental prognostic information Study based on a multicenter retrospective cohort of 1,466 adults Guideline-Based Recommendations
Diagnosis
Evaluate CPP trajectory and cumulative metrics in patients with ABI Management
Maintain CPP within a fixed target range while considering individual variability Monitoring & Follow-up
Monitor ICP and MAP to derive CPP and assess patient status Risks
Increased mortality risk associated with certain CPP trajectory phenotypes Patient & Prescribing Data
Adults with ABI due to TBI, AIS, ICH, or SAH
Dynamic CPP management may improve outcomes in ABI patients
Clinical Best Practices
Utilize trajectory modeling and cumulative metrics for prognostic assessment Consider individual patient physiology when setting CPP targets Implement ICP monitoring as part of standard care in ABI management Related Resources & Content
