Depression and breast cancer: research progress and prospects from an interdisciplinary perspective - Scorecard - MDSpire

Depression and breast cancer: research progress and prospects from an interdisciplinary perspective

  • By

  • Kang He

  • Huiyang Tang

  • Cunjun Mai

  • Yongzhen Li

  • Dongmin Yu

  • June 2, 2026

  • 0 min

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Clinical Scorecard: Interdisciplinary Insights into the Relationship Between Depression and Breast Cancer: Advances and Future Directions

At a Glance

CategoryDetail
Condition
Key MechanismsOveractivation of the HPA axis, elevated glucocorticoids, dysregulation of sex hormone axis, immune cell suppression, pro-inflammatory cytokines, neuroimmune dysregulation.
Target Population
Care Setting

Key Highlights

  • High prevalence of depression (up to 32.2%) among breast cancer patients.
  • Interdisciplinary approaches are necessary for effective management of comorbidity.

Guideline-Based Recommendations

Diagnosis

  • Assess for depression in breast cancer patients due to high comorbidity rates.

Management

  • Utilize interdisciplinary approaches combining psychological and biomedical interventions.

Monitoring & Follow-up

  • Regularly evaluate mental health status in breast cancer patients.

Risks

  • Neglecting psychosocial factors may adversely affect treatment adherence and recovery.

Patient & Prescribing Data

Breast cancer patients experiencing depressive symptoms.

Attention to drug interactions between antidepressants and breast cancer medications is crucial.

Clinical Best Practices

  • Integrate psychological support with cancer treatment.
  • Implement cognitive-behavioral therapy and mindfulness-based interventions.

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Original Source(s)

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