Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population - Scorecard - MDSpire

Age-Dependent Variations in the Relationships Between LDL-C, TG/HDL-C Ratio, and Carotid Plaque: Insights from a Large Cross-Sectional Study in a Chinese Health Screening Cohort

  • By

  • Zeda Li

  • Biqiong Zhu

  • Kui Chen

  • Xiangdang Long

  • Kang Zhao

  • July 20, 2026

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Clinical Scorecard: Age-Dependent Variations in the Relationships Between LDL-C, TG/HDL-C Ratio, and Carotid Plaque: Insights from a Large Cross-Sectional Study in a Chinese Health Screening Cohort

At a Glance

CategoryDetail
ConditionCarotid atherosclerosis
Key MechanismsLDL-C and TG/HDL-C as independent predictors of carotid plaque
Target PopulationAdults undergoing health screenings
Care SettingHealth Promotion Center of a major tertiary-level hospital

Key Highlights

  • Carotid plaque detection rate was 31.4% among participants.
  • LDL-C and TG/HDL-C are independently associated with carotid plaque.
  • LDL-C association is strongest in individuals aged <40 years.
  • TG/HDL-C association remains stable across age groups.
  • LDL-C correlates with hypoechoic plaques.

Guideline-Based Recommendations

Diagnosis

  • Use carotid ultrasonography for assessing carotid plaque.

Management

  • Consider age-specific lipid assessment strategies.

Monitoring & Follow-up

  • Regular monitoring of LDL-C and TG/HDL-C levels in adults.

Risks

  • Increased risk of cardiovascular events associated with elevated LDL-C.

Patient & Prescribing Data

Adults aged 18 years and older without established cardiovascular events.

LDL-C and TG/HDL-C levels should be evaluated in the context of age.

Clinical Best Practices

  • Incorporate age stratification in lipid assessment.
  • Utilize TG/HDL-C ratio as a practical tool in primary care settings.

Related Resources & Content

Original Source(s)

Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population

  • by Zeda Li, Biqiong Zhu, Kui Chen, Xiangdang Long, Kang Zhao

  • July 20, 2026

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