The vasoactive-age adjusted sepsis-induced coagulopathy score predicts 28-day new-onset multiple organ dysfunction syndrome in patients with sepsis: a single-centre retrospective cohort study - Scorecard - MDSpire

The vasoactive-age adjusted sepsis-induced coagulopathy score predicts 28-day new-onset multiple organ dysfunction syndrome in patients with sepsis: a single-centre retrospective cohort study

  • By

  • Ke-jun Cao

  • Jia-qi Ge

  • Hong-zhi Fang

  • July 6, 2026

  • 0 min

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Clinical Scorecard: The Vasoactive-Age Adjusted Sepsis-Induced Coagulopathy Score as a Predictor of 28-Day New-Onset Multiple Organ Dysfunction Syndrome in Sepsis Patients: A Retrospective Cohort Analysis from a Single Centre

At a Glance

CategoryDetail
ConditionSepsis
Key MechanismsIncorporates age and vasopressor use into the Sepsis-Induced Coagulopathy score.
Target PopulationAdult sepsis patients meeting Sepsis-3.0 criteria.
Care SettingSingle-centre retrospective cohort study.

Key Highlights

  • VAS score AUC of 0.777, outperforming SIC and qSOFA scores.
  • Optimal cut-off for VAS ≥ 4 shows 76.4% sensitivity and 73.2% specificity.
  • Dynamic VAS increase (ΔVAS>0) correlates with a 4.78-fold higher MODS risk.

Guideline-Based Recommendations

Diagnosis

  • Use VAS score for early identification of sepsis patients at high risk of MODS.

Management

  • Incorporate VAS score in early sepsis risk stratification.

Monitoring & Follow-up

  • Monitor dynamic changes in VAS score over time.

Risks

  • Age and vasopressor use are significant predictors of MODS.

Patient & Prescribing Data

495 adult sepsis patients admitted between January 2019 and June 2023.

Combination of VAS score with biomarkers like lactate and procalcitonin enhances predictive value.

Clinical Best Practices

  • Utilize VAS score alongside traditional scoring systems for comprehensive assessment.
  • Consider age and vasopressor use in treatment planning for sepsis patients.

Related Resources & Content

Original Source(s)

The vasoactive-age adjusted sepsis-induced coagulopathy score predicts 28-day new-onset multiple organ dysfunction syndrome in patients with sepsis: a single-centre retrospective cohort study

  • by Ke-jun Cao, Jia-qi Ge, Hong-zhi Fang

  • July 6, 2026

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