HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis - Scorecard - MDSpire

HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis

  • By

  • Dongling Li

  • Qinrui Cai

  • Ling Lin

  • Li Li

  • Yao Chen

  • Tianlin Feng

  • Xiaoya Zhou

  • Jia Xie

  • Xiaohong Fu

  • Chuanwei Li

  • Jun Xiao

  • Fan Yang

  • June 16, 2026

  • 0 min

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Clinical Scorecard: Inhibition of Colorectal Cancer Growth through HDAC1-Driven CDK1 Decrotonylation via Cell Cycle and Apoptosis Regulation

At a Glance

CategoryDetail
Condition
Key MechanismsLysine crotonylation regulates chromatin dynamics and CDK1 activity, influencing tumor behavior.
Target Population
Care Setting

Key Highlights

  • CDK1 K9 decrotonylation enhances sensitivity to CDK1 inhibitors by altering protein interactions.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Assessing specific biomarkers related to cell cycle arrest and apoptosis in response to CDK1 modifications.

      Risks

        Patient & Prescribing Data

        Decrotonylation of CDK1 may improve efficacy of CDK1 inhibitors, but monitor for potential side effects.

        Clinical Best Practices

        • Incorporate findings into clinical trials and patient management strategies for CRC.

        Related Resources & Content

        Original Source(s)

        HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis

        • by Dongling Li, Qinrui Cai, Ling Lin, Li Li, Yao Chen, Tianlin Feng, Xiaoya Zhou, Jia Xie, Xiaohong Fu, Chuanwei Li, Jun Xiao, Fan Yang

        • June 16, 2026

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