Accumulation of embryos to improve outcomes in advanced-age women undergoing IVF/ICSI cycles: a retrospective cohort study
-
By
-
Mingya Cao
-
Yue Wang
-
Liang Zhou
-
Kexin Xing
-
Huanjun Li
-
Yuanyuan Liu
-
Qingyun Sun
-
Xuli Zhu
-
Zhiming Zhao
-
July 7, 2026
-
Clinical Scorecard: Enhancing IVF/ICSI Success Rates in Older Women Through Embryo Accumulation: Findings from a Retrospective Cohort Analysis
At a Glance
| Category | Detail |
|---|
| Condition | In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment in advanced-age women |
| Key Mechanisms | Embryo accumulation strategy prior to embryo transfer |
| Target Population | Advanced-age female patients undergoing IVF/ICSI |
| Care Setting | Assisted reproductive technology (ART) clinics |
Key Highlights
- Embryo accumulation significantly increases cumulative live birth rate (CLBR) and cumulative clinical pregnancy rate (CCPR) in advanced-age women.
- The strategy is most effective when the number of accumulated embryos does not exceed two.
- No significant difference in miscarriage rates between embryo accumulation and control groups.
Guideline-Based Recommendations
Diagnosis
- Assess reproductive potential in women over 35 years of age.
Management
- Consider embryo accumulation through consecutive stimulation cycles for advanced-age women undergoing IVF/ICSI.
Monitoring & Follow-up
- Monitor cumulative embryo number and its association with reproductive outcomes.
Risks
- Be aware of potential confounding factors in retrospective studies.
Patient & Prescribing Data
Women aged 38 years and older undergoing IVF/ICSI treatment.
Cumulative embryo number positively correlates with pregnancy outcomes up to a threshold of two embryos.
Clinical Best Practices
- Implement individualized treatment strategies based on comprehensive assessments of age, physical status, and economic conditions.
- Utilize propensity score matching to eliminate baseline confounding bias in studies.
Related Resources & Content
