Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China - Scorecard - MDSpire
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Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China
Clinical Scorecard: Microbial Agents and Antimicrobial Resistance Patterns in Pediatric Acute Appendicitis: A Retrospective Analysis from a Tertiary Care Center in Ningbo, China
At a Glance
Category
Detail
Condition
Acute Appendicitis
Key Mechanisms
Luminal obstruction of the appendix and subsequent bacterial infection
Target Population
Children aged below 18 years
Care Setting
Tertiary hospital
Key Highlights
E. coli was the predominant pathogen isolated (55.12%)
High resistance rates of E. coli to ampicillin (84.56%) and trimethoprim-sulfamethoxazole (55.67%)
Polymicrobial infections were more common in gangrenous appendicitis (42.07%) compared to non-gangrenous (33.70%)
P. aeruginosa showed low resistance to tested agents (≤2%)
C. testosteroni exhibited high resistance to ciprofloxacin (72.82%)
Guideline-Based Recommendations
Diagnosis
Clinical diagnosis supported by imaging and treated with appendectomy
Pathological confirmation of acute appendicitis
Management
Appendectomy is the mainstay of treatment
Preoperative antimicrobial management may include metronidazole and cephalosporins
Monitoring & Follow-up
Monitor antimicrobial resistance patterns in local pathogens
Risks
Increased risk of polymicrobial infection in gangrenous appendicitis
Patient & Prescribing Data
Empiric reliance on third-generation cephalosporins may be insufficient due to high E. coli resistance.
