Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999–2025
By
Muhammad Atif Mazhar
Abdal Ahmad
Vishan Das
Danyal Ahmad
Kaneez Fatima
Muhammad Mukhlis
Eshal Atif
Zubair Ahmed
Sadia Qazi
July 16, 2026
Clinical Scorecard: Mortality Trends and Inequities Related to Atherosclerotic Cardiovascular Disease and Stroke Among Adults in the U.S., 1999–2025
At a Glance
Category Detail
Condition Atherosclerotic Cardiovascular Disease and Stroke Key Mechanisms Overlap of risk factors and clinical consequences between ASCVD and stroke. Target Population Adults aged ≥25 years in the United States. Care Setting Population-based analysis of mortality trends.
Key Highlights
Overall average age-adjusted mortality rate (AAMR) was 15.01 per 100,000. Mortality declined from 26.82 in 1999 to 10.91 per 100,000 in 2025. Mortality burden remains higher among men, older adults, and Black individuals. Significant increase in mortality rates observed among adults aged 25–44 years after 2015. Persistent disparities in mortality rates across demographic and geographic groups. Guideline-Based Recommendations
Diagnosis
Utilize death-certificate data to identify coexisting ASCVD- and stroke-related conditions. Management
Implement equitable prevention strategies targeting high-burden populations. Monitoring & Follow-up
Track mortality trends by sex, age group, race/ethnicity, and geographic location. Risks
Recognize higher mortality rates among non-metropolitan populations and specific racial/ethnic groups. Patient & Prescribing Data
Adults aged ≥25 years with ASCVD and stroke-related conditions.
Focus on prevention and risk-factor modification in high-burden demographics.
Clinical Best Practices
Adopt an integrated vascular medicine approach for risk assessment and prevention. Ensure accurate documentation of coexisting conditions on death certificates. Related Resources & Content
