Clinical Scorecard: Long-Term Results of One-Anastomosis Gastric Bypass: A Comprehensive Review of Studies with a Minimum Follow-Up of 10 Years
At a Glance
Category
Detail
Condition
Obesity and obesity-related metabolic diseases
Key Mechanisms
Hypo-absorptive single gastrojejunal anastomosis procedure leading to sustained weight loss and metabolic improvements
Target Population
Adult patients undergoing primary or conversion bariatric surgery
Care Setting
Metabolic and bariatric surgery centers
Key Highlights
OAGB accounts for 7.6% of bariatric procedures worldwide, with higher prevalence in Europe and Asia-Pacific regions.
Mean total weight loss at 10 years post-OAGB ranges from 27.6% to 32.1%, demonstrating durable weight loss.
Remission rates at 10 years include approximately 79% for type 2 diabetes and hypertension, with notable improvements in GERD and OSA symptoms.
Guideline-Based Recommendations
Diagnosis
Assess eligibility for metabolic surgery based on international BMI thresholds and obesity-related comorbidities.
Management
Consider OAGB as a primary or revisional bariatric procedure for sustained weight loss and metabolic disease remission.
Monitor and address potential nutritional deficiencies and bile reflux during long-term follow-up.
Monitoring & Follow-up
Regular long-term follow-up to evaluate weight loss maintenance, metabolic disease remission, and late complications.
Surveillance for nutritional deficiencies and symptoms of bile reflux or gastroesophageal reflux disease.
Risks
Potential for bile reflux and nutritional deficiencies requiring monitoring and management.
Conversion surgery required in approximately 3–6% of patients over 10 years.
Patient & Prescribing Data
Adult patients undergoing OAGB for obesity and metabolic disease
OAGB provides durable weight loss (~31% total weight loss at 10 years) and high remission rates of T2D and hypertension (~79%), with a low rate of conversion surgeries (3–6%).
Clinical Best Practices
Use standardized definitions for remission of obesity-related diseases to evaluate outcomes.
Employ multidisciplinary follow-up to monitor nutritional status and manage late complications.
Inform patients about the potential risks of bile reflux and nutritional deficiencies prior to surgery.
Consider OAGB as a viable long-term bariatric option given its sustained efficacy and safety profile.
