Neuroimaging and neurophysiologic biomarkers for diagnosis and prognosis of depressive disorders, bipolar disorder, anxiety disorders, obsessive compulsive disorder, posttraumatic stress disorder, and substance use disorder: an evidence map - Scorecard - MDSpire

Neuroimaging and neurophysiologic biomarkers for diagnosis and prognosis of depressive disorders, bipolar disorder, anxiety disorders, obsessive compulsive disorder, posttraumatic stress disorder, and substance use disorder: an evidence map

  • By

  • Catherine Sowerby

  • Adrienne Landsteiner

  • Kristen Ullman

  • Maylen Anthony

  • Caleb Kalinowski

  • Michele R. Spoont

  • Scott Sponheim

  • Kelvin Lim

  • Jose V. Pardo

  • Timothy J. Wilt

  • Wei Duan-Porter

  • May 6, 2026

  • 0 min

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Clinical Scorecard: Neuroimaging and Neurophysiological Markers for the Diagnosis and Prognosis of Mood Disorders, Anxiety Disorders, Obsessive-Compulsive Disorder, PTSD, and Substance Use Disorders: A Comprehensive Evidence Review

At a Glance

CategoryDetail
ConditionMood Disorders, Anxiety Disorders, OCD, PTSD, Substance Use Disorders
Key MechanismsNeuroimaging and neurophysiological biomarkers for diagnosis and treatment response.
Target PopulationAdults with psychiatric disorders.
Care SettingClinical settings utilizing neuroimaging and neurophysiological assessments.

Key Highlights

  • Advancements in precision medicine for mental health through biomarkers.
  • Systematic collection of neuroimaging datasets shows promise for identifying psychiatric disorder biomarkers.
  • Challenges remain in translating neuroimaging techniques into clinical practice.
  • Evidence map conducted to assess the state of research on neuroimaging and neurophysiological tests.
  • Focus on diagnosis and prognosis of multiple mental health disorders.

Guideline-Based Recommendations

Diagnosis

  • Utilize neuroimaging techniques to improve diagnostic accuracy.

Management

  • Incorporate neurophysiological assessments in treatment planning.

Monitoring & Follow-up

  • Regularly evaluate treatment response using neuroimaging biomarkers.

Risks

  • Consider clinical heterogeneity and symptom overlap when interpreting neuroimaging results.

Patient & Prescribing Data

Adults with depressive disorders, bipolar disorder, anxiety disorders, OCD, PTSD, and SUD.

Precision medicine approaches may enhance treatment efficacy through tailored interventions.

Clinical Best Practices

  • Integrate neuroimaging and neurophysiological assessments into routine clinical evaluations.
  • Encourage participation in large-scale studies to advance understanding of psychiatric disorders.

References

Original Source(s)

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