Case Report: Recurrent uterine inflammatory myofibroblastic tumor harboring IGFBP5-ALK fusion with sustained response to iruplinalkib - Scorecard - MDSpire

Case Report: Recurrent uterine inflammatory myofibroblastic tumor harboring IGFBP5-ALK fusion with sustained response to iruplinalkib

  • By

  • Ke Zhao

  • Min Hu

  • Runfeng Yang

  • Yi Huang

  • June 12, 2026

  • 0 min

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Clinical Scorecard: Case Study: Persistent Uterine Inflammatory Myofibroblastic Tumor with IGFBP5-ALK Fusion Exhibiting Continued Response to Iruplinalkib

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPostmenopausal women with recurrent uterine IMT.
Care Setting

Key Highlights

  • Add detail about the patient's initial misdiagnosis as uterine myxoid leiomyoma and leiomyosarcoma.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Regular imaging surveillance (CT or MRI) to assess treatment response and disease progression.

      Risks

        Patient & Prescribing Data

        Sequential therapy with ALK inhibitors (crizotinib followed by iruplinalkib) may optimize treatment outcomes.

        Clinical Best Practices

        • Involve a multidisciplinary team for complex cases like IMT.

        Related Resources & Content

        Original Source(s)

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