Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trial
By
Jiao Liu
Wenjuan Zhang
Xiaohui Li
Danting Jia
Zhixia Bai
Xuexin Chen
May 26, 2026
Clinical Scorecard: Impact of Lidocaine on Postoperative Pain Management Following Modified Radical Mastectomy: Insights from a Secondary Analysis of a Randomized Controlled Trial
At a Glance
Category Detail
Condition Postoperative pain following modified radical mastectomy Key Mechanisms Intravenous lidocaine reduces acute postoperative pain and attenuates systemic inflammatory response Target Population Patients undergoing modified radical mastectomy for breast cancer Care Setting Perioperative anesthesia management
Key Highlights
Lidocaine infusion significantly reduced resting and active NRS scores at 24 h postoperatively. Lower serum levels of inflammatory markers observed in lidocaine groups compared to controls. No significant differences in anesthetic and analgesic consumption or adverse events among groups. Guideline-Based Recommendations
Diagnosis
Evaluate postoperative pain using the numerical rating scale (NRS). Management
Consider intravenous lidocaine as an adjunct for pain management in MRM. Monitoring & Follow-up
Monitor NRS scores and inflammatory markers postoperatively. Risks
Be aware of potential adverse events associated with lidocaine infusion. Patient & Prescribing Data
Patients scheduled for modified radical mastectomy.
Lidocaine may reduce opioid consumption and improve pain control.
Clinical Best Practices
Implement multimodal analgesia strategies in perioperative care. Utilize intravenous lidocaine for its analgesic and anti-inflammatory properties. Related Resources & Content
