Psychological Stress, Self-Reported Anxiety, and Depression in Women Diagnosed with Takotsubo Syndrome
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By
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Runa Sundelin
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Christina Ekenbäck
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Jonas Spaak
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Peder Sörensson
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Loghman Henareh
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Per Tornvall
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Patrik Lyngå
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January 19, 2026
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Clinical Scorecard: Psychological Stress, Self-Reported Anxiety, and Depression in Women Diagnosed with Takotsubo Syndrome
At a Glance
| Category | Detail |
|---|
| Condition | Takotsubo Syndrome |
| Key Mechanisms | Acute heart failure syndrome mimicking myocardial infarction with reversible left ventricular dysfunction. |
| Target Population | Women, primarily postmenopausal, aged 35-70. |
| Care Setting | Cardiology, specifically in the context of myocardial infarction diagnosis. |
Key Highlights
- Takotsubo syndrome predominantly affects women, especially postmenopausal.
- High levels of depressive symptoms and illness-related anxiety are observed in affected women.
- Stressful incidents often trigger the syndrome.
- Cortisol levels are linked to cardiovascular risk factors but show no significant differences in takotsubo patients compared to controls.
- Self-rated stress and anxiety levels are elevated in women with takotsubo syndrome.
Guideline-Based Recommendations
Diagnosis
- Diagnosis confirmed via cardiac magnetic resonance imaging (CMR) showing specific left ventricular wall motion abnormalities.
Management
- Monitor psychological symptoms and manage stressors in patients.
Monitoring & Follow-up
- Evaluate salivary cortisol levels and psychological assessments at follow-up.
Risks
- Increased risk of anxiety and depression post-acute event.
Patient & Prescribing Data
Women diagnosed with takotsubo syndrome, primarily postmenopausal.
Focus on psychological support and stress management.
Clinical Best Practices
- Incorporate psychological assessments in routine follow-up for takotsubo syndrome patients.
- Educate patients on the importance of stress management.
References
