Translational development and first-in-human compassionate infusion of NK-92 cells expressing a CD5-based chimeric antigen receptor (SRCD5CAR-NK-92) in a patient with multidrug-resistant fusariosis - Scorecard - MDSpire

Translational development and first-in-human compassionate infusion of NK-92 cells expressing a CD5-based chimeric antigen receptor (SRCD5CAR-NK-92) in a patient with multidrug-resistant fusariosis

  • By

  • María Velasco-de-Andrés

  • Pedro Puerta-Alcalde

  • Jiri Eitler

  • Lydia Krutz

  • Mariana Chumbita

  • Marta Español-Rego

  • Cristina Català

  • Laura Carrillo-Serradell

  • Violeta Planells-Romeo

  • Lucía Aragón-Serrano

  • Andrea Vergara

  • Amanda Isabel Pérez-Valencia

  • Patricia Monzó-Gallo

  • Antonio Gallardo-Pizarro

  • María Teresa Cibeira

  • Alexandru Vlagea

  • José Luis Caro

  • Eduard Palou

  • María Suárez-Lledó

  • Alex Soriano

  • Gonzalo Calvo

  • Álvaro Urbano-Ispizua

  • Torsten Tonn

  • Carolina Garcia-Vidal

  • Francisco Lozano

  • May 8, 2026

  • 0 min

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Clinical Scorecard: First-in-Human Compassionate Use of NK-92 Cells with a CD5 Chimeric Antigen Receptor (SRCD5CAR-NK-92) for Treating Multidrug-Resistant Fusariosis

At a Glance

CategoryDetail
ConditionMultidrug-Resistant Invasive Fungal Infection (IFI) - ensure terminology consistency.
Key MechanismsUse of SRCD5CAR-NK-92 cells targeting β-glucans to enhance antifungal activity - clarify mechanism details.
Target PopulationPatients with multidrug-resistant fungal infections, particularly those with hematological malignancies - ensure alignment with source.
Care SettingClinical setting under compassionate use approval - confirm details from source.

Key Highlights

  • First-in-human use of SRCD5CAR-NK-92 cells for MDR IFI - add metrics.
  • Superior antifungal activity compared to untransduced NK-92 cells - provide data.
  • Escalating intravenous infusions administered without significant adverse effects - specify observed effects.

Guideline-Based Recommendations

Diagnosis

  • Identify invasive fungal infections in immunocompromised patients - ensure alignment with source.

Management

  • Consider SRCD5CAR-NK-92 cells for patients with limited therapeutic options - expand on management strategies.

Monitoring & Follow-up

  • Monitor for local and systemic adverse effects during treatment - clarify specifics.

Risks

  • Potential for cytokine storm and alloreactivity, though not observed in this case - provide context.

Patient & Prescribing Data

Patients with hematological malignancies and MDR fungal infections - ensure consistency.

Escalating doses of irradiated SRCD5CAR-NK-92 cells were administered safely - clarify safety profile.

Clinical Best Practices

  • Utilize allogeneic NK cells for off-the-shelf CAR-NK therapies - expand on rationale.
  • Conduct further investigations on efficacy and long-term outcomes - specify study designs.

References

Original Source(s)

Translational development and first-in-human compassionate infusion of NK-92 cells expressing a CD5-based chimeric antigen receptor (SRCD5CAR-NK-92) in a patient with multidrug-resistant fusariosis

  • by María Velasco-de-Andrés, Pedro Puerta-Alcalde, Jiri Eitler, Lydia Krutz, Mariana Chumbita, Marta Español-Rego, Cristina Català, Laura Carrillo-Serradell, Violeta Planells-Romeo, Lucía Aragón-Serrano, Andrea Vergara, Amanda Isabel Pérez-Valencia, Patricia Monzó-Gallo, Antonio Gallardo-Pizarro, María Teresa Cibeira, Alexandru Vlagea, José Luis Caro, Eduard Palou, María Suárez-Lledó, Alex Soriano, Gonzalo Calvo, Álvaro Urbano-Ispizua, Torsten Tonn, Carolina Garcia-Vidal, Francisco Lozano

  • May 8, 2026

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