TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice - Scorecard - MDSpire

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

  • By

  • Rong Tang

  • Banglian Hu

  • Sulan Xie

  • Yijun Shen

  • Ziwei Wang

  • Xingyi Wang

  • Xiaohua Huang

  • Guoqiang Fei

  • Weifeng Peng

  • Honghua Zheng

  • Jing Ding

  • Xin Wang

  • June 8, 2026

  • 0 min

Share

Clinical Scorecard: TPPU Mitigates Seizures and Associated Comorbidities by Targeting the Akt/mTOR Pathway in Mice with KA-Induced Convulsions

At a Glance

CategoryDetail
Condition
Key MechanismsInhibition of soluble epoxide hydrolase (sEH) and suppression of Akt/mTOR pathway activation (ensure sourcing).
Target Population
Care Setting

Key Highlights

  • TPPU significantly mitigated seizure severity in KA-induced chronic epileptic mice.
  • Behavioral assessments indicated reduced anxiety and depressive-like behaviors.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Not applicable (preclinical study in mice)

          TPPU administered at 1 mg/kg/d for 3 to 7 days prior to seizure induction.

          Clinical Best Practices

            Related Resources & Content

            Original Source(s)

            TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

            • by Rong Tang, Banglian Hu, Sulan Xie, Yijun Shen, Ziwei Wang, Xingyi Wang, Xiaohua Huang, Guoqiang Fei, Weifeng Peng, Honghua Zheng, Jing Ding, Xin Wang

            • June 8, 2026

            Related Content

            Cognition Associated With Future Depression Risk

            Lower cognition is associated with later depression in controls, while higher cognition is associated with relapse in remitted depression

            Can Lower Music Levels Preserve Workout Intensity?

            Despite preserved exertion perceptions, researchers report limited hearing protection use in group fitness classes.

            Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation