TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice - Scorecard - MDSpire
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TPPU Mitigates Seizures and Associated Comorbidities by Targeting the Akt/mTOR Pathway in Mice with KA-Induced Convulsions

  • By

  • Rong Tang

  • Banglian Hu

  • Sulan Xie

  • Yijun Shen

  • Ziwei Wang

  • Xingyi Wang

  • Xiaohua Huang

  • Guoqiang Fei

  • Weifeng Peng

  • Honghua Zheng

  • Jing Ding

  • Xin Wang

  • June 8, 2026

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Clinical Scorecard: TPPU Mitigates Seizures and Associated Comorbidities by Targeting the Akt/mTOR Pathway in Mice with KA-Induced Convulsions

At a Glance

CategoryDetail
Condition
Key MechanismsInhibition of soluble epoxide hydrolase (sEH) and suppression of Akt/mTOR pathway activation (ensure sourcing).
Target Population
Care Setting

Key Highlights

  • TPPU significantly mitigated seizure severity in KA-induced chronic epileptic mice.
  • Behavioral assessments indicated reduced anxiety and depressive-like behaviors.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Not applicable (preclinical study in mice)

          TPPU administered at 1 mg/kg/d for 3 to 7 days prior to seizure induction.

          Clinical Best Practices

            Related Resources & Content

            Original Source(s)

            TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

            • by Rong Tang, Banglian Hu, Sulan Xie, Yijun Shen, Ziwei Wang, Xingyi Wang, Xiaohua Huang, Guoqiang Fei, Weifeng Peng, Honghua Zheng, Jing Ding, Xin Wang

            • June 8, 2026

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