Fenestration Re-creation for Early Fontan Deterioration: Long-Term Hemodynamic and Clinical Outcomes - Summary - MDSpire

Fenestration Re-creation for Early Fontan Deterioration: Long-Term Hemodynamic and Clinical Outcomes

  • By

  • Thi Hai Yen Tran

  • Yoshihiko Kurita

  • Maiko Kondo

  • Yosuke Fukushima

  • Yusuke Shigemitsu

  • Yuya Kawamoto

  • Mayuko Hara

  • Hirokazu Tsukahara

  • Tatsuo Iwasaki

  • Shingo Kasahara

  • Kenji Baba

  • May 9, 2026

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Objective:

To evaluate the clinical outcomes and hemodynamic changes after recreating spontaneously closed fenestration in Fontan patients over a defined follow-up period.

Key Findings:
  • No significant differences in baseline characteristics between the two groups.
  • Group 1 had a median interval of 42 days from Fontan completion to fenestration re-canalization.
  • Longitudinal hemodynamic changes were assessed, revealing specific differences in outcomes between the two groups.
Interpretation:

Recreating fenestration in Fontan patients with spontaneous closure may improve clinical outcomes and hemodynamic status, although further studies with larger sample sizes are needed to confirm these findings.

Limitations:
  • Retrospective observational design limits causal inferences.
  • Sample size may not be sufficient to generalize findings.
Conclusion:

Fenestration re-canalization may serve as a beneficial intervention for selected Fontan patients experiencing early decline, warranting further investigation.

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