To summarize current findings on how modulation of the gut microbiota may improve intestinal thermotolerance and strengthen barrier function, providing insights for the prevention and treatment of heat stroke (HS), particularly in the context of climate change.
Key Findings:
Heat stroke (HS) is increasingly prevalent due to climate change and can lead to severe health complications.
Intestinal injury is a critical factor in HS pathogenesis, characterized by increased permeability and 'leaky gut.'
Heat stress disrupts gut microbiota, reducing beneficial bacteria and promoting opportunistic pathogens.
Probiotics may help maintain gut microbiota balance and enhance intestinal barrier function, potentially reducing HS severity.
Gut–organ communication networks may explain how HS leads to injury beyond the intestine.
Interpretation:
The gut microbiota plays a significant role in the pathogenesis of HS, and its modulation may offer a therapeutic avenue, though most evidence is preclinical and the interactions with other organs are complex.
Limitations:
Much of the evidence is derived from animal studies, limiting direct applicability to humans.
The clinical relevance of findings related to fungal dysbiosis in HS remains unclear.
Differences in microbiota composition and heat tolerance between species may affect translational relevance.
The implications of gut microbiota modulation on human health require further exploration.
Conclusion:
Modulating gut microbiota could be a promising strategy for HS prevention and management, but urgent further clinical studies are needed to confirm these findings in light of the rising incidence of HS.
