To investigate the association between BNP/LVEF and atrial fibrillation and evaluate its discriminative performance specifically in a hospitalized population.
Key Findings:
45.6% of patients had atrial fibrillation.
Higher BNP/LVEF values were independently associated with increased AF risk (OR, 1.02; 95% CI, 1.01–1.04).
Significant non-linear association observed with a sharp increase in AF risk at lower BNP/LVEF levels (P-nonlinear < 0.001).
BNP/LVEF demonstrated good discriminatory ability for AF (AUC = 0.84).
Subgroup analysis revealed significant heterogeneity across sex, smoking, alcohol consumption, and coronary heart disease status.
Interpretation:
BNP/LVEF is a valuable integrative marker for assessing AF risk, providing insights into cardiac stress and function that may enhance clinical risk stratification in hospitalized patients.
Limitations:
Single-center study may limit generalizability.
Observational design does not establish causation and may introduce biases.
Potential confounding factors not fully accounted for.
Conclusion:
BNP/LVEF is independently and nonlinearly associated with atrial fibrillation, showing good discriminative performance, suggesting its utility in clinical risk stratification.
Adjunctive tirofiban was associated with higher rates of excellent 90-day outcomes after inadequate tenecteplase response in selected stroke patients, though adjusted analyses were not significant.
