A review of the pathogenic mechanism and clinical management progress of in-stent calcification restenosis - Summary - MDSpire

A review of the pathogenic mechanism and clinical management progress of in-stent calcification restenosis

  • By

  • Xiangchen Xia

  • Fei Luo

  • Jianchun Li

  • Quanyi Liu

  • Jianzhong Pang

  • Fuyun Jia

  • Qiang Xu

  • Chao Peng

  • May 29, 2026

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Objective:

To summarize the pathophysiological mechanisms, imaging evaluation, and advances in the clinical management of coronary in-stent calcific restenosis.

Key Findings:
  • Calcification restricts stent expansion and exacerbates neointimal hyperplasia and neoatherosclerosis, increasing ISR risk.
  • High-resolution imaging techniques provide insights into calcification morphology and its impact on restenosis.
  • Novel therapies have improved the management of calcific ISR.
Interpretation:

Limitations:
  • The review does not provide specific clinical trial data to support the efficacy of the novel therapies discussed.
  • Future research directions are proposed but not detailed.
Conclusion:

The article synthesizes current knowledge on calcific ISR.

Original Source(s)

A review of the pathogenic mechanism and clinical management progress of in-stent calcification restenosis

  • by Xiangchen Xia, Fei Luo, Jianchun Li, Quanyi Liu, Jianzhong Pang, Fuyun Jia, Qiang Xu, Chao Peng

  • May 29, 2026

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