Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies - Summary - MDSpire
Advertisement
Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies
To evaluate the impact of frailty on major clinical outcomes, both short- and long-term, in patients aged ≥75 years undergoing percutaneous coronary intervention (PCI).
Key Findings:
Frail patients aged ≥75 years had a higher risk of in-hospital death (RR = 3.16, 95% CI: 1.28–7.78) and all-cause death (RR = 2.51, 95% CI: 1.78–3.56).
Frailty increased the risk of complications, including bleeding (RR = 2.26, 95% CI: 1.54–3.31) and stroke (RR = 1.90, 95% CI: 1.86–1.94).
The evidence quality was rated low across all outcomes.
Interpretation:
Frailty significantly increases the risk of adverse outcomes following PCI in elderly patients, underscoring the need for careful risk assessment, shared decision-making, and individualized management strategies.
Limitations:
Low GRADE evidence quality indicates uncertainty in findings.
Potential bias in included studies due to observational nature.
Possible publication bias affecting the results.
Conclusion:
Frailty is associated with increased risks of mortality and complications in patients aged ≥75 years undergoing PCI, necessitating individualized management strategies.
Diagnosing Parkinson’s disease has long depended primarily on clinical expertise — careful neurologic examination, longitudinal symptom assessment and the nuanced interpretation of movement abnormalities.
Epilepsy remains a life-altering condition, particularly due to the unpredictable nature of seizures and their cumulative impact on cognition, independence and quality of life.
