Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients - Summary - MDSpire

Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients

  • By

  • Xiaolong Bai

  • Zhijun Wang

  • Ziyi Cao

  • Junping Zhen

  • May 28, 2026

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Objective:

To evaluate coronary inflammation and insulin resistance using FAI and TyG index, and assess their associations with coronary heart disease (CHD) and functional ischemia in patients with MAFLD.

Key Findings:
  • TyG index and FAI were independent risk factors for CHD and coronary functional ischemia (P<0.05).
  • Nomogram showed excellent discrimination (ROC-AUC 0.952) for identifying high-risk CHD patients.
  • Nomogram effectively predicted coronary functional ischemia in MAFLD patients with CHD (AUC 0.904).
  • FAI and TyG index were positively correlated with CHD and functional ischemia risk.
Interpretation:

The study evaluates the relationship between systemic metabolic dysfunction and local coronary inflammation, with a focus on the nomogram's role in CHD risk stratification in MAFLD patients.

Limitations:
  • The study is limited to a specific patient population with MAFLD, which may affect generalizability.
  • Reliance on non-invasive measures may not capture all aspects of coronary health.
Conclusion:

The findings indicate that FAI and TyG index are associated with CHD risk in MAFLD patients.

Original Source(s)

Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients

  • by Xiaolong Bai, Zhijun Wang, Ziyi Cao, Junping Zhen

  • May 28, 2026

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