Atorvastatin and almonertinib-induced myopathy in a polypharmacy context: a case report - Summary - MDSpire

Atorvastatin and almonertinib-induced myopathy in a polypharmacy context: a case report

  • By

  • Jifang Zhou

  • Lixia Yu

  • Huimin Xu

  • May 14, 2026

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Objective:

To report a case of myopathy potentially induced by the concurrent use of atorvastatin and almonertinib in an elderly patient, highlighting its significance in clinical practice.

Key Findings:
  • The patient exhibited markedly elevated serum creatine kinase (CK) levels (2,103 U/L) after atorvastatin was added to his regimen, one day post-initiation.
  • Discontinuation of atorvastatin and almonertinib led to normalization of CK levels.
Interpretation:

The interaction between atorvastatin and almonertinib, both of which are influenced by CYP3A4, likely contributed to the development of myopathy in this patient, necessitating awareness of CYP3A4's role in drug metabolism.

Limitations:
  • The case study is based on a single patient, limiting generalizability.
  • Lack of detailed clinical documentation on the interaction between atorvastatin and almonertinib in the literature, and absence of follow-up data.
Conclusion:

For patients requiring both almonertinib and cholesterol-lowering medications, alternatives to atorvastatin, such as PCSK9 inhibitors or cholesterol absorption inhibitors, should be considered to minimize the risk of myopathy, underscoring the need for further research on drug interactions.

Original Source(s)

Atorvastatin and almonertinib-induced myopathy in a polypharmacy context: a case report

  • by Jifang Zhou, Lixia Yu, Huimin Xu

  • May 14, 2026

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