Objective:
To analyze how genetic background and environment shape human biology through a multiomics survey of healthy adults across different ancestry groups and continents.
Key Findings:
- Ethnicity showed strong associations with immune, metabolic, pathogen, and microbiome features.
- South Asian participants had higher pathogen-reactive antibody signatures.
- Individuals of European ancestry exhibited greater gut microbial diversity and elevated levels of lipid and metabolite classes linked to cardiovascular and metabolic risk.
- Geography influenced molecular and microbial profiles, with shifts in cholesterol, bile acid, and arachidonic acid pathways observed in participants living outside their ancestral regions.
- Biological age varied by geography, with East Asian participants showing lower biological age in East Asia and European ancestry participants showing lower biological age in the US and Canada.
Interpretation:
The study provides an open-access dataset that enhances understanding of how molecular and microbial baselines differ across populations, potentially refining precision medicine.
Limitations:
Conclusion:
The resulting dataset offers a comprehensive resource for studying human molecular diversity and its implications for health.
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
