Caries May May Signal Oral Antibiotic Resistance - Summary - MDSpire

Caries May May Signal Oral Antibiotic Resistance

  • By

  • Andrea Surnit

  • May 29, 2026

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Objective:

To analyze the differences in antibiotic resistance and biofilm-forming capacity of supragingival bacteria in patients with active dental caries compared to healthy controls.

Key Findings:
  • 21% of Veillonella parvula isolates from patients with caries were susceptible to ampicillin compared to 73% from healthy patients.
  • 79% of isolates from patients with caries were moderate biofilm producers, while 82% from healthy patients were non-biofilm producers.
  • Resistant bacteria in healthy patients were more frequently associated with stronger biofilm formation.
  • Moderate and strong biofilm-producing isolates showed higher antimicrobial resistance compared to non-biofilm producing isolates.
  • Beta-lactamase activity was confirmed in eight bacterial isolates, predominantly in Fusobacterium nucleatum.
Interpretation:

Remove this section.

Limitations:
  • Small sample size and uneven species representation across groups.
  • Potential intra-subject dependency due to multiple isolates from the same patient.
  • Culture-based design limited analysis to cultivable bacteria, missing broader ecological interactions.
Conclusion:

Remove this section.

Original Source(s)

Caries May May Signal Oral Antibiotic Resistance

  • by Andrea Surnit

  • May 29, 2026

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